ABSTRACT
Introduction: In 2020–2022, Russia, like the rest of the world, faced the COVID-19 pandemic. The necessity to overcome its challenges has led to the expansion of powers of the regions. To improve public policy, it is expedient to evaluate the effectiveness of measures taken by the regions for public health preservation. Such an evaluation is proposed to be carried out using the public health index, which requires the development of appropriate methodological approaches. Objective: To develop and test a methodological approach to analyzing the effectiveness of public policy measures in terms of preserving public health. Materials and methods: This work continues a series of studies on establishing the public health index in the Russian Federation, which has already developed an approach to calculating this indicator in view of medical and social resources of the population. The approach is based on the recommendations of the World Health Organization standard "The Urban Health Index". The evaluation of the effectiveness of public policy measures involves the implementation of several stages for calculating the public health index and the classification of Russian regions depending on the degree of its change for 2019-2022. When performing calculations, correlation analysis is used to identify indicators that do not contradict each other. Through the normalization of indicators, as well as the calculation of average geometric values, the calculation of the public health index is carried out. The data for calculating the public health index are taken from the website of Rosstat and the Ministry of Health of Russia. Results: We established deterioration of public health indicators in most regions. We believe that this finding is primarily related to the COVID-19 pandemic as a large–scale challenge. In 2022, the public health index for the Russian Federation has decreased by 13.15 % compared with 2019. The largest decline has been observed in the Saratov Region (69.14 %). At the same time, an increase in the public health index has been registered in several regions, e.g. by 6 % over the study period in the Tyumen Region. Conclusion: The analysis of the components of the public health index makes it possible to ascertain the cause of public health worsening in the region and to assess its determinants. Having classified the regions, it is important to identify the determinants of public health that can be influenced through public policy instruments. © 2023, Federal Center for Hygiene and Epidemiology. All rights reserved.
ABSTRACT
Introduction: The COVID-19 pandemic has demonstrated the need to improve methods of public health assessment and approaches to the development of a system for its monitoring in the Russian Federation. Public health represents a sociomedical resource of the society, deterioration of which has a negative effect on the potential of the society to resist emerging threats. Within a series of previous studies, the authors have developed a methodological approach to calculating the public health index, the monitoring of which will facilitate managerial decisions aimed at strengthening of the potential of public health. Objective: To test a methodological approach to calculating the public health index in the regions of the Russian Federation. Materials and methods: To estimate the public health index, we applied an original methodology specially developed with account for strategic goals outlined by the Russian President and provisions of the WHO Handbook for calculation and use of the Urban Health Index. It includes correlation assessment and standardization of parameters. The components of the public health index were selected in view of the requirements established by the presidential decree on preserving the population of the country, developing the human potential, and strengthening national defense capabilities. Results: We calculated Russian regional values of the public health index for the year 2019. The year selection was determined by the absence of significant biological challenges, currently posed by the COVID-19 pandemic, and the aftermath of the pension reform. The estimated mean of the public health index in the Russian Federation in 2019 was 0.238, with extremes established in the Yamalo-Nenets Autonomous Okrug (0.458) and the Kurgan Region (0.036). Conclusions: Public health monitoring involves tracking of achieved values of the public health index and its individual constituents as they allow judgment on the potential of the society to counteract external threats. Further research should be aimed at analyzing changes in the public health index in the regions of Russia during and after large-scale biological and social challenges. It seems expedient to consider the issue of creating a national information portal devoted to public health problems in the country. © 2022, Federal Center for Hygiene and Epidemiology. All rights reserved.
ABSTRACT
: Lung cancer is the most commonly occurring cancer in men worldwide. To search for new biological markers of this pathology, the transcriptome of the blood mononuclear cells from patients and healthy donors (residents of Kemerovo oblast, Russia) was studied using SurePrint G3 Human Gene Expression microarray technology. A total of 288 differentially expressed genes were identified, including 108 up-regulated genes and 180 down-regulated genes. Functional enrichment analysis using the WebGestalt resource and different databases (Gene Ontology, KEGG, and Reactome) indicated changes in the expression profiles of genes involved in the processes of immune response, protein synthesis, cell cycle control, and apoptosis. Analysis of protein–protein interactions using the STRING algorithm made it possible to identify functional clusters of gene products with different expression levels.
ABSTRACT
Objective: to study the potential for the development of financing the Compulsory Health Insurance (CHI) system in Russia. Material and methods. Оur research estimates the amount of funds available in the CHI system based on fractal analysis and ARIMA modeling. The proposed approach makes it possible to determine the critical amount of funds in the CHI system. Once the limit is reached, the chance of violating the economic security requirements will increase. Results. Аn increase in the volume of available funds in the CHI sector is expected in the mid-term perspective on the verge of quarter 1, 2023. The amount of funds required to pay for medical care for the respective period of time will increase by 0.77% quarterly. Conclusion. Gaining additional funds might be possible by optimizing the internal networks for generating cash flows in the CHI system, as well as applying additional ways of financing medical care (particularly Voluntary Health Insurance policies). It would be practical to redistribute the functions of financing health care between the Federal Fund for CHI and its territorial branches. It is essential to review the role of health insurance companies in monitoring the health care quality by improving the communication with citizens. © 2021 IRBIS LLC.